Annabelle Townsend spent years designing the three-quarter-length sleeve that adorns her arm. “Every component was picked for a reason,” she says, including Big Ben, musical notes and one of her favorite quotes. (A tattoo sleeve, like the sleeve of a shirt, covers the arm.) “I drew it over and over until I had perfected it.” Townsend wanted the tattoo to be a collection of many things that were meaningful to her. “I designed the entire thing over a few years,” she says of the three-quarter sleeve that now adorns her right arm. celebrated her eighteenth birthday with a trip to the tattoo shop.
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If you are an author contributing to an RSC publication, you do not need to request permission To request permission to reproduce material from this article, please go to the A more sensitive imaging contrast agent could enable earlier cancer detection or help guide surgical resection of tumors, both of which have been shown to significantly improve patient survival.Ī colorful approach towards developing new nano-based imaging contrast agents for improved cancer detection If further developed, these coloring agents could play important roles in the clinical setting. After intravenous injection, fluorescence imaging revealed significant localization of the new “optical ink” liposomal nanoparticles in all three tumor models as opposed to their neighboring healthy tissues ( p < 0.05). Mouse xenograft models of colorectal, cervical and lymphoma tumors were used to evaluate the newly developed nano-based imaging contrast agents. The best performing optical inks (Green 8 and Orange 16) were further incorporated into liposomal nanoparticles to assess their tumor targeting and optical imaging potential. We found that some of these coloring agents, coined as “optical inks”, exhibit a multitude of useful optical properties, outperforming some of the clinically approved imaging dyes on the market. We characterized their absorption, fluorescence and Raman scattering properties in the hopes of identifying a new panel of dyes that offer exceptional imaging contrast. The pigments are often used in tattoo inks and the dyes are FDA approved for the coloring of foods, drugs, and cosmetics. In this study, we evaluate the optical properties of a colorful class of dyes and pigments that humans routinely encounter. Development of new imaging agents could offer improved early cancer detection during routine screening or help surgeons identify tumor margins for surgical resection. Providing physicians with new imaging agents to help detect cancer with better sensitivity and specificity has the potential to significantly improve patient outcomes.